Bacterial diseases have altered history from pneumococcal pneumonia to bubonic plague to tuberculosis all killing untold millions in their process. Most of us do not concern ourselves to a great extent with bacterial infections that would have terrified people less than one hundred years ago. The leading killer in the pre-antibiotic era was essentially conquered by the advent of antibiotics and average human lifespan increased dramatically. During most of human history, the number one cause of death was infection.

Printed on acid-free paper Springer is part of Springer Science+Business Media (ForewordĪ strong case can be made that up to this point among the most important scientific achievements in history has been the discovery and development of antibiotics to treat bacterial infections. The publisher makes no warranty, express or implied, with respect to the material contained herein. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Pucci Executive Director Achillion Pharmaceuticals New Haven, CT, USA Dougherty Senior Principal Scientist AstraZeneca Pharmaceuticals LP 35 Gatehouse Dr.

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